Search results for " separation"
Article
Efforts Accelerate to Streamline Postapproval Change Process
Manufacturers and regulatory authorities seek coordinated lifecycle management policies.
By Jill Wechsler
Frequent revisions and updates in manufacturing processes and operations are routine…
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
Article
Perfusion in the 21st Century
Cell separation devices have also become more efficient, allowing for very high cell densities to be achieved. It should be noted, however, that further developments in this area are needed, because i…
Article
Affinity Chromatography Handbook in 3 Volumes
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
Article
Downstream Processing Continues to Worry CMOs
Article
Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
Article
Managing Biomanufacturing Capacity Expectations
Capacity for complex therapeutics is becoming increasingly difficult to predict.
By Randi Hernandez
Demand for any given new product is typically only known after significant investments h…
Poster
Process economy effects of modernizations in vaccine purification
One technique is core bead chromatography, which allows for dual functionality, combining size separation with bind-elue chromatography. This poster describes the technique using influenza virus produ…
Article
Selection Guide Size Exclusion Chromatography Columns and Media
Size exclusion chromatography (SEC), also called Gel filtration (GF), separates molecules on the basis of differences in size as they pass through a SEC medium packed in a column. A variety of media…
Article
Continuous Processing for the Production of Biopharmaceuticals
…s upstream processing, commonly called perfusion, there has also been extensive development of other separation technologies such as continuous chromatography, refolding, precipitation, cell lysis, f…