Search results for " expression" in Articles / App Notes

Article Determining Criticality–Process Parameters and Quality Attributes Part III: Process Control Strategies—Criticality throughout the Lifecycle
These mathematical expressions can be represented graphically as either contour or 3-D response surface plots. Even this view of the design space is too simplistic. To ensure a process has a…

Article Best Practices in Adopting Single-Use Systems
Bioprocessors must first analyze benefits and risks for their specific situation, keeping in mind their expression system, process, product, and corporate objectives. After determining the suitabil…

Article Trends in Downstream Bioprocessing
Expression systems are producing 5 times what they were 10 years ago. • Current downstream/purification areas were not designed to handle this increase in production. • Buffer capacity, colu…

Article Navigating Emerging Markets: Middle East and North Africa
The pharmaceutical industry grows despite conflict in the Middle East. The Middle East and North Africa have been rocked in recent years by upheaval ranging from moderate protest to full…

Article A Platform Approach for the Purification of Domain Antibodies (Dabs)
This Application note describes a three-step purification process of a domain antibody (Dab) expressed in the periplasm of E. coli. First, a capture step using Capto™ L was used to reduce E. coli host…

Article The Future of Biopharma
…t clinical and commercial scale • continuous processing, including perfusion • high-tech expression systems and other genetic engineering advances • automation, monitoring, and process co…

Article Quality by design for biotechnology products—part 1
In summary, protein design and engineering are powerful tools for enhancing efficacy, modulating immunogenicity, altering proteolytic stability, introducing chemical modification sites, and improving …

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