Search results for " future" in Articles / App Notes
Article
Automating Processes in Upstream Processing
…h and then trying to provide the agility within the software to cope with the process changes in the future. Customers are looking for new product introductions (NPIs) to take place in their faciliti…
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Improving Process-Scale Chromatography
In the immediate future, downstream bioprocessing will likely involve hybrid solutions with both single-use and stainless-steel equipment and limited linkage of unit operations.
While there are no…
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Efforts Accelerate to Streamline Postapproval Change Process
Another FDA guidance, published in April 2016, encourages manufacturers to utilize comparability protocols, also known as PACMPs in the European Union, to outline planned future changes and how they w…
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Mixing dynamics in a large volume single use mixer
Dissolution studies will be used in the future to understand the liquid-liquid and powder-liquid mixing times along with zone mapping and test validation.
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Article
Downstream Processing Continues to Worry CMOs
This could be seen as a leading indicator of future problems for biotherapeutic developers, whose problems are gradually increasing in their own right.
CMOs are trying out various approaches to …
Article
Generating a Fully Processed Antibody
The high level of FGE expression did not significantly impact cell growth and doubling time for this clone, and it was selected as the lead candidate for future work.
Table I: Formylglycin…
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Microbiological Testing: Time is of the Essence
Assays that can be performed near the bioreactor location and in real time are definitely the assays for the future.
References
1. International Council for Harmonisation, Q5A (R1) Viral Safety …
Article
Vaccine Development Faces Urgency and Challenges
Gavi, “Ebola vaccine purchasing commitment from Gavi to prepare for future outbreaks,” Press Release, Jan. 20, 2016.
4. D. Ridley, X. Bei, E. Liebman, Health Affairs 35 (2) (February 2016).
5.…
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Continuous Processing for the Production of Biopharmaceuticals
While improvisation at each step is important, future research needs to focus on integration of the multiple unit operations into a single process and optimization of the entire bioprocessing train as…
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Despite the aforementioned drawbacks, the potential automation of the system may result in future efforts to further develop electro-responsive systems.
Photo-responsive substrates based on differ…