Search results for "bioprocess"
Article
Case Study: Oncolytic Adenovirus Production
Oncolytic viruses constitute a promising therapeutic approach for treatment of cancer. These viruses selectively replicate in tumor cells and effectively kill these cells without harming normal cell…
Poster
A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
Adenovirus (AdV) vectors are commonly used in cancer gene therapy trials and evaluated for use in vaccines for various diseases. In this study, we have combined technical evaluation of process steps a…
Article
Addressing the Complex Nature of Downstream Processing with QbD
Joey Studts, director late-stage downstream development in the bioprocessing development biologicals department at Boehringer Ingelheim (BI), notes that large-molecule products have more input parame…
Poster
Perfusion Media Development for Scalable Processes
Finally, operating at very low CSPR will allow for mammalian cell bioprocesses to run as true chemostat cultures in the future.
In this study, we demonstrate a general workflow to develop high-pe…
Article
Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…
Poster
Scaling In-Line Buffer Preparation from Process Development to Manufacturing
This poster demonstrates how ÄKTA™ avant can be used to replicate the BioProcess™ IC System in bench scale.
Article
Case Study: Process for Production of Oncolytic Adenovirus
The promising results from clinical studies on the use of viral vectors to address important medical needs have spurred interest in developing scalable and cost-efficient manufacturing processes. Here…
Article
Supply Chain Challenges for Single-Use Systems
Isberg (Entegris): I always refer people to the BPSA quality test matrices guide (5), which is an excellent resource for quality testing for single-use systems for bioprocessing applications.
Bulp…
Resource
Affinity, Stockholm, Sweden
This meeting has a long tradition, where scientists and engineers from academia and industry meet to exchange knowledge in the field of affinity technology, molecular recognition and its application i…
Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
The cost pressure on biopharmaceuticals drives the industry toward exploring process intensification options that will maintain or improve quality, stability, and manufacturability of the product wh…