Search results for "Mabs" in Articles / App Notes
Article
Development of Purification for Challenging Fc-Fusion Proteins
In response, titers for monoclonal antibodies (mAbs) and Fc-fusion proteins have significantly increased (1-5).
Particularly for Fc-fusion proteins, these improvements have resulted in a …
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…
Article
Process Chromatography Selection for Downstream Processing Applications
Separation Technologies
BioPharm: What are the most commonly used separation technologies for biologics that are not monoclonal antibodies (mAbs)?
Björkman (Cytiva): If one excludes mAbs, then…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
If we look at how the mAbs were purified, it was mostly based on platforms. With the same process or with very small adjustment, you could purify multiple different targets or multiple different targe…
Article
Cytiva Advances Fiber Chromatography Technology with New Launch
Using Ology Bio’s mAb platform, we have gained two orders of magnitude greater productivity using Fibro PrismA than MabSelect PrismA resin,” said Ryan Davis, senior scientist at Ology Biosciences, in …
Article
Witnessing Major Growth in Next-Generation Antibodies
Challener
Next-generation antibodies are designed to be more specific and are often more potent than traditional monoclonal antibodies (mAbs). As a result, their commercial potential is significan…
Article
Trends in BioPharma Approvals in 2013
mAbs are glycoproteins, carrying an oligosaccharide side chain attached to asparagine residue 297 of the antibody’s heavy chains. This glycocomponent plays a central role in triggering antibody-depend…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
The following article describes the development of a purification platform for monoclonal antibodies (MAbs) at Pfizer's Global Biologics division, including how the individual unit operations have bee…
Article
A Closer Look at Affinity Ligands
Bioprocess scientists and engineers realized the importance of affinity chromatography in purification of mAbs in the early 1980s and identified a small, 42 kD protein (i.e., Protein A) that has excep…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Digitalization of bioprocessing operations, equipment, and facilities can improve workflow and output, but maintaining data integrity is a concern.
By Feliza Mirasol
The advancement of digit…