Search results for " mammalian"
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
Background
The development of serum-free mammalian cell-culture media technology has been impressive during the past few decades. The advances can perhaps best be appreciated when compared directl…
Article
Platform Approach Speeds Process Development
…uticals such as recombinant monoclonal antibodies is dependent on high performing bioprocesses using mammalian host cells. Chinese hamster ovary (CHO)-based cell culture platforms should combine stat…
Article
Tools for Continuous Bioprocessing Development
This is especially important for mammalian cells such as Chinese hamster ovary (CHO) cells due to their shear sensitivity.
The circulation time is also an important parameter, since it affects the …
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
In addition to high cell density mammalian expression, expanded utilization of other expression systems such as microbial and yeast will support these newer biotherapeutics (BioTx). The diversity of B…
Article
Digitalization: The Route to Biopharma 4.0
In microbial cell cultures, scale down models such as micro well plates (3) and deep well plates are employed, whereas shake tubes/flasks are widely used in mammalian cultures (4). However, most of th…
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Improving Upstream Predictability
One example is the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC), a National Science Foundation (NSF)-funded cooperative with 25 corporate members, which is focusing on upstream bioman…
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Leveraging Computational Models of Glycosylation for Biopharma QA
Large-scale mammalian cell culture is used for the manufacture of all therapeutic glycoproteins (TGPs), with Chinese hamster ovary (CHO) and murine myeloma (NS0 and Sp2/0) cell lines being the most-co…
Article
Challenges in Cell Harvesting Prompt Enhancements
Other improvements in mammalian cell harvesting that have been developed with the use of fully hermetic centrifuges include management of the air-liquid interface at both the inlet and outlet zones by…
Article
QbD Improves Cell-Culture Process Control
al, “Quality by Control: Towards Model Predictive Control of Mammalian Cell Culture Bioprocesses [2],” Biotechnology Journal online, DOI: 10.1002/biot.201600546, March 31, 2017.