Search results for " columns"
Article
Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer.
By Jennifer Markarian
A digital twin is a model of a proces…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Hahn points out that, for instance, pre-packed single-use chromatography columns of the same type may differ in terms of column packing and resin lot capacity. “In practical application, these differe…
Article
Purify App: Finding What You Need for Protein Purification
…ystem to match your application?
Visit the NEW purify app to:
• select resins, prepacked columns, and empty columns
• configure and visualize ÄKTA systems in 3D
• find accessor…
Article
New HiScale™ 10/40 for Scale-Down Studies
Cytiva is pleased to announced the new HiScale™ 10/40.
HiScale 10/40 column is especially suitable for scale-down studies used in, for example, viral clearance evaluation in downstream processing. …
Article
Chromatography Scale-Up: Don’t Get Tied Down by Bed Height
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When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.
Keeping a constant residence time is a well-est…
Article
Going Small to Achieve Success on the Commercial Scale
…erably with scale, contending with increasing wall effects inherent in small-diameter chromatography columns, and accounting for differences in detector-specific path lengths and the associated non-l…
Article
A Closer Look at Affinity Ligands
The matrix is typically in the form of small 50–150 micron beads that are highly porous to provide a large surface area, maximizing antibody binding potential for higher yields from fixed-volume colum…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
There are also small, miniature columns that can be utilized in the same way. So that will speed up the experiments that you're running, but also utilize the design of experiment, where you want to ge…
Article
Moving PAT from Concept to Reality
The learning curve for process analytical technology has slowed widespread adoption.
By Cynthia A. Challener
alexlmx a- Stock.Adobe.com
Process analytical technology (P…
Article
How to Determine Dynamic Binding Capacity (DBC) of Chromatography Resins
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In protein purification, dynamic binding capacity (DBC) of a chromatography column describes the maximum amount of target protein that you can load onto your co…