Search results for " columns"
Article
The Challenge of Disruptive Technologies in Bioprocessing
The Challenge of Disruptive Technologies in BioprocessingIncreasing demand for biologics is driving the need for innovation in bioprocessing.
Jul 01, 2018
Increasing demand for biologics is drivin…
Article
Impurity Testing of Biologic Drug Products
“Other host cell proteins and binding agents carried over from purification columns may mimic the action of the therapeutic protein in assays, leading to mis-formulation of the product outside the the…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Several talks focused on the utilization of miniaturized columns, such as Robocolumns, and if they could become an even more important tool going forward and especially in late -tage development. For …
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Protein A chromatography columns are frequently too large, limiting the use of prepacked devices and consuming larger than necessary quantities of buffer.
Cytiva stated in a recent press rel…
Article
Process Chromatography: Continuous Optimization
…ncreased by using smaller particle size resins and operating at slightly higher pressures in smaller columns, according to Deorkar. The higher particle surface areas result in greater efficiency.
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Article
Improvements in Protein A Chromatography
At the same time we see promise in non-bead based protein A technologies like membrane adsorbers and monoliths, which have higher productivity than packed columns due to their short bed heights and hi…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Traditional manufacturing processes for biologics make use of large, fed-batch reactors and oversized chromatography columns that end up wasting time or material. Alternatively, upstream process scale…
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The objective of this study was to assess the impact of manufacturing-scale, freeze-thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) u…
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
Compared with conventional chromatography, using stainless steel columns, the use of ReadyToProcess Adsorber membranes can help reduce capital investment, consumption of buffers and other process liqu…
Article
Use of Multivariate Data Analysis in Bioprocessing
Apr 06, 2015
By Anurag S. Rathore, Sumit K. Singh
BioPharm International
The ever increasing demand of biotherapeutics, together with the pressure to contain healthcare costs have motiva…