Search results for " protein" in Articles / App Notes
Article
Selecting the Right Viral Clearance Technology
The success of viral clearance depends on the selection of appropriate methods that ensure the removal or destruction of any viruses without affecting the target protein. Several factors must be consi…
Article
Use of Multivariate Data Analysis in Bioprocessing
MVDA applications in cell-culture operations
Cell-culture operations are by far the most common platform used for production of protein therapeutics. In this endeavor, various advanced offline and…
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Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
Conversely, the more novel the protein is, the less opportunity there may be to apply knowledge across products.
After assigning an impact score, the team then evaluates the quantity and relevanc…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In addition, some protein-, VLP-, and killed virus-based non-live vaccines require addition of an adjuvant to improve their immunogenicity due to their non-replicating nature.
Spo…
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Can Vaccine Development Be Safely Accelerated?
They possess a surface spike (S) glycoprotein that binds to host cell receptors, and the nature of this protein is believed to determine the main properties of each coronavirus. SARS-CoV was the first…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Blincyto targets cell surface proteins CD19 and CD3 simultaneously, helping to put T cells within reach of the targeted cancer cell with the goal of allowing the T cells to inject toxins into cancer c…
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Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
On a therapeutic protein, the composition of these glycans can significantly impact the drug’s stability, pharmacokinetics, and biological activity. Thus, glycan structure is a critical quality attrib…
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Binding models
A key aspect in modeling of IEC is that of the choice of model for protein binding. There are dozens of adsorption models available in the literature. Most of the models are based on …
Article
A Bright Future for the Plasma Fractionation Industry
Some of the examples given by Perreault were in the area of recombinant plasma proteins, disruptive technologies, and especially improved diagnosis of patients and better access to therapeutics. Perre…
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Trends in Downstream Bioprocessing
In addition, while many firms would like to avoid the high cost of Protein A affinity resin, most find it difficult to make such changes to their processes, and their reluctance is compounded by the f…