Search results for " protein" in Articles / App Notes
Article
Web Chat June 19: Challenge Cytiva Scientists with Multistep Purification
Automated multistep (or multidimensional) protein purification is used to free up time, increase throughput, and reduce intermediate sample storage.
Join us for a free, one-hour web chat to dis…
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NIST Spectroscopic Measurement Standards
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Ultraviolet (UV) absorbance measurements provide a rapid and reliable method to determine protein concentrations. The National Institute of Standards and Technology (NIST) has developed St…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
These nano-scale membrane sacs are mediators of intercellular communication and can be exploited as carriers of therapeutic molecules (like proteins and RNA) that can alter disease states.
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Process Development: What May Lie Ahead in 2018?
Such next-gen antibodies include antibody drug conjugates, engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar antibody therapies.
The productio…
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Critical Quality Attributes Challenge Biologics Development
Determination of criticality of process and quality attributes improved significantly in the past decade with the advancement of knowledge in protein engineering, biology, and cell culture engineering…
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Downstream Processing for Cell-Based Therapies
Typically, a swing-bucket rotor centrifugation step or a filtration step is included to remove cell debris, large aggregates, unwanted proteins, volume reduce (i.e., concentrate), and formulate the ce…
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Walk Away and Do More Screening Preps
Many analyses require purified protein, and substantial hands-on time might be allocated to this task. Learn how an ÄKTA pure protein purification system can be modified to increase throughput of…
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An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
By Mark Plavsic
Use of continuous cell lines in the manufacture of biological therapeutic products, such as vaccines, recombinant proteins, and monoclonal antibodies, is associated with the concom…
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
This method, widely named trypsinization, is based on the addition of an active concentration of the enzyme to the cell culture and subsequent digestion of cell-membrane proteins that establish the in…
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Biopharma Advances Demand Specialized Expertise
With this in mind, substitution of HPLC for UPLC, rapid microbiological screening methods, and investment in automated approaches to complex analytical problems such as protein sequencing are now bein…