Search results for " capture" in Articles / App Notes
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
So experiments that are performed for modeling aim to capture the dynamics of the interaction between the biomolecules and the ligand. This can be realized by running, for example, linear gradient exp…
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Get Started: Purification of mAb Variants - eLearning
- Understand which resins are suitable for the first capture step.
- Discover the different strategies for removal of product- and process-related impurities in the polishing steps.
ACCESS TRAIN…
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Chromatography innovations for the diversified antibody pipeline
MabSelect™ VH3 resins provides efficiency in capture of bispecific antibodies and antibody fragments such as Fab, scFv, and VHH. Discover how we’re supporting the diverse antibody pipelines with chrom…
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A scalable single-use two-step plasmid purification process
The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRN…
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Chromatography processes for the diversified therapeutic antibody pipeline
The diversity of antibody variants in today’s pipeline presents unique challenges for purification and we see molecules such as bsAbs, Fabs, dAbs, and others. Conventional chromatography protocols, …
Article
Fundamentals of hydrophobic interaction chromatography
Hydrophobic interaction chromatography (HIC) is a versatile technique that can be used for capture, intermediate purification, or polishing steps.
This technique separates proteins accor…
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Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
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Current Techniques and Challenges Presented in Scaling Between Bioreactors
…dreas Castan: The organizations which includes CMOs have acquired elaborated template available that captures the critical information, and operating parameters for the transfer process related infor…
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Alkaline stability of Fc and VH3 binding in protein A resins
In the development of antibody purification protocols, you need to know your Ab molecule and its possible affinity binding sites for the chromatography resins. In this study, we have looked at…
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Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator Bioscience AB develops antibody-based pharmaceuticals for cancer treatment, specializing in mono- and bispecific antibodies for tumor-directed immunotherapies. Alligator and Cytiva devel…