Search results for "Cytiva" in Articles / App Notes
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Managing Risk in Biomanufacturing
We simply cannot avoid all risks and the stakes are high in the biopharmaceutical industry. With patients’ lives dependent on a continuous supply of high-quality drugs and vaccines, it is essential …
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Tips for Protein Purification Method Editing
Protein purification questions and answers from ÄKTA club web chat.
Find out how to quickly generate tailored automation methods in your UNICORN™ software in this blog.
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The Extreme Costs of a Bioburden Incident
The cost of bioburden incidents can vastly outweigh the costs of preventing them. Read the bioburden article series.
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Sources of Bioburden You Might Have Missed
A problem with traditional mAb manufacturing is that there are so many potential entry points for microbial contamination. There are, however, ways to shut the door on contamination.
The risk …
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Step 1: Estimation of Äkta chromatograph parameters
A zero-volume connector should be used to determine the flow parameters for the external volume of the Äkta chromatograph (Cytiva)…
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HTPD: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…
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Speed and Flexibility Are Dual Goals for Biopharma Operations
The facilities, built in partnership with Cytiva, offer cGMP manufacturing based on mammalian cell culture technologies to meet customer demand for Phase II/III clinical trials. In addition, the singl…
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Accelerated flavivirus vaccine production with modern tools and solutions
Flavivirus vaccine development and production constitute many challenges and can be both space-and resource-consuming. This white paper gives an overview of modern tools and solutions, adding flexib…
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Efficient concentration of a low-titer bovine IgG with high recovery in low volume
This application note describes the design of circuits with low working volume, allowing for high concentration of dilute feed streams. The use of ReadyCircuit™ single-use assemblies allowed for as…
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High Throughput Protein Purification at a Glance
Within the Human Protein Atlas project, scientists are using ÄKTA systems to purify up to 180 protein samples per week. The project uses antibodies to study the localization of proteins in huma…