Search results for "Cytiva" in Articles / App Notes
Article
Validation of the production of influenza virus in ReadyToProcess WAVE™ 25 bioreactor system
This application note describes the validation of the single-use ReadyToProcess WAVE 25 rocking bioreactor system in production of influenza virus from Vero cells in microcarrier-based cultures. A 2…
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A Platform Approach to Purification of Antibody Fragments
Antibody fragments constitute a promising class of biopharmaceutical products. As compared with full length antibodies, their fragments have unique properties that make them favorable for certain th…
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Modeling Bioreactor Performance
…cale-down), according to Ken Clapp, senior manager for applications, integration, and technology at Cytiva. “Performance may be as much about the integration of the bioreactor in the overall biomanuf…
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High-Throughput Process Development Handbook
Time-to-clinic and time-to-market are two key factors for successful biopharmaceutical development. Efficient development of the manufacturing process is a crucial component of the overall project…
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Mixing dynamics in a large volume single use mixer
Large volume single-use technology mixers can be used for mixing operations throughout the entire bioprocess workflow. Large-volume mixers are mainly required in clinical three-scale and production…
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Overcoming Buffer Challenges With In-Line Conditioning
Preparation and storage of the large number of buffers required for biopharmaceutical production can be a challenge, particularly in large production scale. In this application note, we show how in-…
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Simplify chromatography method creation
Method creation is an essential part of preparing for automated protein purification runs. To save time and effort, method creation can be simplified and you can get to the point where you can start…
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Vocabulary of the chromatographer
Similar to other technical areas, chromatographers generate their own vocabulary, all with a good scientific purpose and for a common understanding. However, the same terminology can be used in othe…
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Single-use technologies in downstream process intensification
In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation …
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Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…