Search results for " yield"
Article
Predicting Progress in Protein Aggregation
“Cells may stop secreting a protein if it takes on a new, aggregated form, leading to low titers and reduced yields and productivity. In addition, the formation of larger precipitates can cause the ph…
Article
Evolution of the Monoclonal Antibody Purification Platform
When implemented for a specific product, the revised elution scheme led to a 5% absolute reduction in fragment content with a 10% yield loss.
Gradient elution for cation exchange chro…
Article
Trends in Downstream Bioprocessing
So the issue is, what can we do to increase the concentration of protein in solution without decreasing yields or activity?”
On-going research into new technologies being developed in this industr…
Article
Operational Excellence: More Than Just Process Improvement
Such transformations can yield a multiplicity of operational, organizational, and financial benefits that can be leveraged and sustained into the future. Not the least of these sustainable benefits ar…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Until recently, UHPLC was limited to the application of small molecules, but new developments have yielded promising applications for large molecules such as antibodies. Figure 5 shows a chromatogram …
Article
Stirring up the fermentation game
Both the achieved microbe densities and product yield were shown to be consistent with the performance of conventional stainless steel systems.
Fig 1. XDR-50 MO fermentor vessel and I/O cab…
Article
Quality by Design: A CMO's Perspective on Gaining Knowledge Faster and Better
The main focus of QbD is to ensure that the elements of quality are incorporated into the design of the process and that the process consistently yields a safe and efficacious product. Product underst…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The aim of this white paper is to demonstrate how Cytiva single-use products can be applied in the field of vaccine manufacturing. The white paper includes a brief discussion around modern vacci…