Search results for "chromatography"
Article
Analytical SEC: How Does Back Pressure Relate to Resolution?
High resolution in HPLC is not achieved by applying back pressure to the column. Let’s straighten out what really helps you achieve high-resolution analytical SEC data.
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Article
Bispecific Antibody Purification: Insights and Case Studies
New modalities, like bispecific antibodies, present unique challenges compared to mAb production. For purification, there’s not just one right answer to which strategy to use. Here are some industry…
Article
Four Purification Steps with Buffer Dilutions in One Go? No Problem!
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Free up time by automating the protein purification and by reducing manual interactions. Learn how Shin Isogai at Biozentrum, Basel, harnesses automation to puri…
Article
Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production.
Due to the diversity of viruses, platform solutions are challenging to implement e…
Article
Using Multiple Techniques in Biosimilar Analysis
Similarly, for reporting on quaternary structure, analytical ultracentrifugation (AUC) and size-exclusion chromatography with multi-angle static light scattering (SEC-MALS) are commonly used orthogona…
Article
Prepare for an FDA Bioburden Inspection
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Not sure how to best approach a bioburden problem when an FDA inspection is imminent? Anastasia Lolas, former FDA Biologics License Application (BLA) revi…
Resource
PREP Symposium
PREP 2019 is the longest running, most recognized international scientific conference and exposition driving the field of Preparative and Process Chromatography, organized by expert scientists and eng…
Article
Understanding Validation and Technical Transfer, Part 2
Qualification protocols are used for process equipment, such as tanks, mills, piping systems, autoclaves, ion exchange units, chromatography columns, and stopper washers. Validation protocols are used…
Article
Understanding Validation and Technical Transfer, Part 3
Any purification procedures and processes, such as recrystallization, chromatography, and viral clearance or inactivation, should likewise be characterized and defined. Cell lines, fermentation proces…
Article
Putting Viral Clearance Capabilities to the Test
But removal with chromatography steps is based on the virus envelope characteristics, which can differ among viruses of the same virus family and even among different strains,” he explains.
Anothe…