Search results for " process" in Articles / App Notes
Article
Automated Concentration and Diafiltration of Multiple siRNA Samples
The generation of many variants as candidates requires robust processes for screening to aid in selecting the optimum siRNA candidate. Automation of the production and screening processes has the inhe…
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Sterilization Trends for Single-Use Consumables
Several sterilization process essentials
Contamination poses a huge risk to the production of biologic drug substances and drug products, making sterility assurance imperative, states Christy Eatmon…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
The increasing popularity of single-use bioreactor systems and continuous processing techniques have brought both new opportunities and challenges to upstream bioprocessing. Together, these trends hav…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Now that biosimilars are here to stay, manufacturers are developing processes for cost efficiency and reliability using newer technology to compete with innovator products based on processes 10-15 yea…
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The Challenge of Disruptive Technologies in Bioprocessing
Other drivers relate to gaps in process performance, for example, “the notorious weakness of harvesting technologies in the face of the ever-increasing biomass from highly productive mammalian cell cu…
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Biopharma Seeks Balance
The strategic shift by small companies to focus on rare or orphan diseases that afflict smaller populations altered research and manufacturing processes and also changed business models. Big Pharma sp…
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
However, development and optimization of a process chromatography step presents a major challenge due to the large number of process parameters that can affect the performance of the step. For example…
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Best Practices in Adopting Single-Use Systems
It involves considering the product, scale, process, and corporate objectives that include the value of legacy stainless-steel equipment. Decisions made early in process development and scaleup will a…
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The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.
Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …
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Perfusion in the 21st Century
Batch processing, in which all raw materials are introduced into the bioreactor at the beginning of the cell-culture process, have largely been replaced with fed-batch systems, in which additional nut…