Search results for " downstream"
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Flavivirus Vaccine: Accelerate Development and Production with Modern Tools and Solutions
This article gives an overview of modern tools and solutions, adding flexibility and speed to both upstream and downstream operations in flavivirus vaccine production.
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Speeding Up mAb Purification Using Fiber-based Technology
Learn how to automate high throughput monoclonal antibody (mAb) purification and improve throughput significantly using fiber-based chromatography.
With purification cycles in minutes rather th…
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Flexible Facilities for Viral Vector Manufacturing
For example, for Duchene muscular dystrophy, the need (at current viral titers and downstream process recoveries) is about 200 L of production bioreactor culture per patient.” The batch size influence…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
2019 proved to be an exciting year for biopharmaceutical developers and process engineers, filled with both advancements and lessons. Considering how far the industry has come, what direction will 2…
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Risk Assessment: Studying Chromatography Resin Variability
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Many factors can give rise to process variability, such as variation in different process parameters or raw materials. This article focuses on process robu…
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A New Paradigm in Process Development
Accelerate biologic manufacturing of mAbs, vaccines, and novel biotherapies. Download this e-book for case studies and insights from Janssen, Roivant Sciences, and mAbxience.
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Best Practices for Selecting a Top-Quality Cell Line
byproduct impurities, which requires early downstream involvement to determine the types of impurities that are easy to remove, and consequently influences clone selection.
An experienced team is …
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A Successful First Year for Testa Center
The bioprocess pilot-scale facility in Uppsala, Sweden, has hosted 15 national and international projects and more than 2000 study visits since its opening in 2018.
Testa Center, a not-for-prof…
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Getting it Right from the Start in the Drug Development Process
Both upstream processing and downstream processing can affect critical quality attributes of the drug molecule under development. These effects can result in process-related impurities, product impuri…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Upstream, the most important CQAs include glucose concentration and cell mobility; downstream, they include turbidity, pH, and conductivity. In addition, virus, microbe, and endotoxin monitoring and c…