Search results for " downstream"
Article
Automating the Biomanufacturing Process
Automation implementation
For more than 15 years, biopharmaceutical manufacturers have been implementing automation and control systems, both upstream and downstream, says Christoph Lebl, head of …
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Second, scalable fermentation and downstream processing procedures were developed for each enzyme. These processes avoided the direct use of animal-derived components. Additionally, multiple productio…
Article
Biopharma Seeks Balance
…itoring and closed loop bioreactor control, next-generation sequencing, continuous manufacturing for downstream processes, and a manufacturing platform for continuous bioprocesses (2).
N…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
A cation exchange (CIEX) chromatographic step was developed as part of a collaborative project, where expertise in the field of downstream purification and bioprocessing was combined with specific bio…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
Cell-culture media has been known to significantly impact cell culture performance, downstream processing, as well as product quality (1, 3). While substantial progress has been achieved in this field…
Article
Being Thorough When Transferring Technology
CMC Biologics has an approach where we run six 2000L SUBs in parallel, then harvest and combine the product streams downstream to produce a single drug substance lot, with an equivalent amount of prod…
Article
Single-use Bioreactors Have Reached the Big Time
Commercial choice
As such, Norris sees single-use bioreactor processes designed with the entire workflow in mind, delivering a high quality, optimal biologic titer into the downstream unit operati…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…tion of Biopharmaceuticals
Antibody Production in Microbial Hosts
Single-use Technologies in Downstream Process Intensification
A Risk-Based Genetic Characterization Strategy for Recombin…
Article
Advancing Single-Use Technology Through Collaboration
…the bioreactor, which is far upstream: there are significant purification processes in place further downstream. According to Duncan Low, scientific executive director, Amgen, “Extractables and leach…
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…