Search results for " downstream" in Articles / App Notes
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Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and adenovirus is evaluated as vaccine delivery system in many preclinical and clinical studies…
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Full Single-Use Downstream Process? Not Any Time Soon.
But where we see full single-use upstream processes, downstream is often a hybrid solution. Here’s why SUTs will not completely replace reuse systems in the near future.
Continue reading in this…
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Bioburden Entry Points in Downstream Processing
If you work in bioprocessing, you are no doubt aware of the need to prevent bioburden entry and proliferation, and reduce the complexity of the equipment and processes involved. Anastasia Lolas, for…
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Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…
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Improving Lentiviral Vector Downstream Processing Workflows
However, these downstream workflows are long, require substantial manual labor, and suffer from low yields of infectious virus. This article discusses process development pain points of a modern workf…
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Current Innovations and Practices To Address Microbial Contamination in Downstream Bioprocessing
Bioburden control is an area of serious concern for anyone making mAbs or other biologicals. Manufacturers’ efforts to avoid microbial contamination are today being complemented by development…
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SEC in the Modern Downstream Purification Process
Kevin O'Donnell, “SEC in the Modern Downstream Purification Process,” BioPharm International 28 (3) 2015.
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Your Reliable Downstream Bioprocessing. Our Proven AxiChrom Columns
The goal for biopharmaceutical manufacturers is to develop a process that will deliver material for clinical trials quickly and smoothly, achieve success in these trials, and scale up to commercial …
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Downstream Process Developers: What are Your Antibody Processing Challenges?
We're asking PD scientists to tell us about their biggest challenges developing downstream processes for mAbs and their variants.
Take this short, anonymous survey to share your insights. We’ll …
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Connected, Automated Downstream Process for mAb Screening and Evaluation
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A pre-clinical lab is often faced with the need to constantly evaluate possible ways of increasing capacity and throughput. This study was done to show both proof of p…