Search results for " downstream" in Articles / App Notes
Article
What Drove Biopharma Development in 2014?
In 2014, there was significant increased interest in continuous processing, both upstream and downstream. On the PDF site, this trend was evident based on webinar invitations, as well as in published …
Article
Securing the Single-Use Supply Chain
Large-scale impact
Today, single-use systems are used throughout the entire process chain from upstream to downstream and from bench scale to production scale. In the past, when drugs were manufac…
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Mechanistic Modeling: Does it Have a Future in Process Development?
Novo Nordisk uses mechanistic models for the development of selected downstream process steps. Following his keynote presentation to attendees at the recent HTPD Conference in Italy, Arne Staby, PhD, …
Article
Pharma Investments Reflect Key Industry Trends
Meanwhile, Sanofi’s Genzyme business is investing $80 million at its recently approved facility in Framingham, MA, adding more downstream processing capabilities for Fabrazyme (agalsidase beta), its t…
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Applying GMPs to the BioPharma Supply Chain
They need to understand how variability in raw material quality can have a significant downstream impact on bioprocessing capability and biopharmaceutical product safety.
Traceability, visibility,…
Article
Raw Material Variability
Many of these issues would be upstream in the cell-culture or fermentation step but could also be downstream in purification. The ‘blackbox’ nature of upstream processes makes things doubly difficult.…
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Q&A with Industry Leaders: Rita Peters
Strategies to connect upstream and downstream operations and extend continuous bioprocessing were popular topics in educational sessions at Interphex as were well-attended and interest was strong.
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Article
Outsourcing Trends in Biopharmaceutical Manufacturing
The author highlights the top 10 outsourcing trends revealed during a survey of biopharmaceutical manufacturers.
The biopharmaceutical industry is changing the way it manufactures. According to …
Article
Best Practices in Adopting Single-Use Systems
Key considerations for implementing single-use components or platforms when moving from research to process development.
The adoption of single-use systems in biopharmaceutical production or…
Article
Elucidating Biosimilars Characterization
…differences regarding the manufacturing processes, be it cell lines used, media used, differences in downstream processing or processing between the innovator and the biosimilar process will undoubte…