Search results for " downstream" in Articles / App Notes
Article
Single-use Bioreactors Have Reached the Big Time
Commercial choice
As such, Norris sees single-use bioreactor processes designed with the entire workflow in mind, delivering a high quality, optimal biologic titer into the downstream unit operati…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…tion of Biopharmaceuticals
Antibody Production in Microbial Hosts
Single-use Technologies in Downstream Process Intensification
A Risk-Based Genetic Characterization Strategy for Recombin…
Article
Advancing Single-Use Technology Through Collaboration
…the bioreactor, which is far upstream: there are significant purification processes in place further downstream. According to Duncan Low, scientific executive director, Amgen, “Extractables and leach…
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
But because the chosen methods focused primarily on downstream virus removal or inactivation instead of strategic sourcing of lower-risk starting materials, the efforts had little effect on serum-free…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Process compatibility
Some chemicals necessary for particular cell-detachment procedures may interfere with subsequent downstream processing steps that are unaffected by other alternative detachme…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Viability at harvest was substantially increased for both cell lines with positive implications for the downstream process.
Figure 5: Comparison of (A) c…
Article
CMOs Concerned With Cost of Single-Use Equipment
Given that CMOs expect to increase their budgets by as much as 6% for new technologies to improve upstream and downstream efficiency—with single-use equipment presumably a part of this spending—budget…
Article
Biopharma Advances Demand Specialized Expertise
The main roadblock for continuous processing is downstream processing of proteins, which currently demands discrete and distinct unit operations for removal of impurities, removal of contaminants, con…
Article
Ligand-Binding Assays and the Determination of Biosimilarity
… LBAs are developed by upstream analytical method development groups and subsequently transferred to downstream QC-GMP lot release groups.”
Ligand-binding kinetic assays for biosimilarity testing…