Search results for " titer"
Article
Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
The selected fed-batch culture conditions supported mAb titers of approximately 4 g/L in bioreactor cultures.
Poster
A Scalable Adenovirus Production Process
The process has process economical advantages compared with an existing reference process and includes new technologies and convenient and sensitive virus titer assays.
Article
The Challenge of Disruptive Technologies in Bioprocessing
“One issue that could occur is the load of a high titer product stream from a large-volume bioreactor onto a column with given, limited size and thus limited capacity (similar with filters), and all o…
Article
Putting Viral Clearance Capabilities to the Test
Achieving a satisfactory clearance level can be limited by the virus titer, by cytotoxicity, or by viral interference,” she explains. “These limitations can be addressed by careful study design to opt…
Article
Cleaning Protein A Resins with 1 M NaOH
With increasing mAb titers, the impurity level of the cell culture feed increases. If not removed, these impurities can build up on the protein A resin and start to leach into the process material i…
Article
Single-Use Chromatography: Adapting to Manufacturing Scale
…acturing scale?
This article discusses strategies for meeting the ever-increasing upstream titers and volumes to prevent downstream purification from becoming a bottleneck.
Learn more here
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Top producing clones were selected by titer and growth and could potentially be ready to be scaled up to bioreactor.
Winning Poster
The second day of the conference concluded with the post…
Article
Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
Human embryonic kidney 293 (HEK293) cells are widely used in production of recombinant viruses and proteins because of their stable growth, high transfection level, and ability to produce high viral t…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Increasing upstream titers can make the Protein A chromatography process step the rate-limiting step in downstream purification. Protein A chromatography columns are frequently too large, limiting the…