Search results for " titer"
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
• The increased upstream titers in mAb production seen in recent years may make the Protein A capture step a bottleneck.
• Protein A columns columns are also more prone to bioburden contamination…
Article
Process Chromatography: Continuous Optimization
“An increase in binding capacity will be beneficial for process economy reasons when purifying steadily increasing upstream titers,” he states. Current protein A resins are also exposed to feeds with …
Article
Unifying Continuous Biomanufacturing Operations
Advancements in sensors informing operators on product quality, glycosylation, viral titer, viral antigen amount, and osmolality, specifically, would be of great use to the industry, noted Genzel, and…
Article
Being Thorough When Transferring Technology
Other examples are unexpected low titer compared to process development runs or unexpected filter clogging in depth-filtration steps due to different quality of filtration starting material. An exampl…
Article
Speed and Flexibility Are Dual Goals for Biopharma Operations
…ions—such as advances in bioreactor technology, media, buffers, and cell lines that produce higher titers in smaller systems—reflected an evolution in technology. Other product introductions included…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Essential Pharmaceuticals provides an animal-component free media that boosts titer and enhances protein quality. It can be difficult to change or improve processes with the strict regulations around …
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
The results show virus titer activity was comparable for Cytodex and Cytodex Gamma and there was no observed difference in distribution or cell growth between systems.
Article
Process Chromatography Selection for Downstream Processing Applications
Improvements in upstream processing have increased titers, shifting bottlenecks downstream from being a volumetric issue to where it is mainly the binding capacity of the resin that is limiting.
T…
Article
Perfusion in the 21st Century
Dramatic increases in the titers achievable with fed-batch culture, which reached levels as high as 4.7g/L (3), eventually eliminated the need to pursue continuous processing for increased productivit…
Article
Downstream Processing Continues to Worry CMOs
Downstream continues to fail to keep up with the recent advances in upstream yield and titers.
Reference
1. BioPlan Associates, 13th Annual Report and Survey of Biopharmaceutical Manufacturi…