Search results for "scale up"
Article
Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
Article
Robust Optimization, Simulation, and Effective Design Space
Jul 01, 2015
By Thomas A. Little, PhD
BioPharm International
Volume 28, Issue 7, pg 40–44
Approaches to the generation of process models, optimization techniques, and application of …
Article
Optimizing Resin Performance with Disposable Chromatography Solutions
On the vendor side, the use of novel polypropylene-based materials is allowing prepacked columns to scale up to 60 cm in diameter, where the cost of scaling up conventional glass columns increases alm…
Article
Best Practices in Adopting Single-Use Systems
Key considerations for implementing single-use components or platforms when moving from research to process development.
The adoption of single-use systems in biopharmaceutical production or…
Article
What is process development?
Ultimately, you will need a process that translates to a manufacturing environment, one that is easy to scale up throughout clinical trials and to the market. By the time you reach Phase III in the dr…
Article
Enhancing Resins Addresses Purification Concerns
However, scale up of these methods can be challenging due to process efficiency and reproducibility.
The most common large-scale process for purification of mRNA, for example, is affinity ch…
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
Mechanistic modeling is considered a part of smart process development, which is a collection of approaches to get better process outcomes and speed up process development.
This week, Bioproce…
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
READ ARTICLE >>
In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was per…
Article
Experience Compact Scalability
Cost and speed are critical components in biomanufacturing. Can you get a good balance between these two things for your purification tasks, whether you are developing a process or manufacturing at pi…
Article
Chromatography Scale-Up: Don’t Get Tied Down by Bed Height
Click here to read the article >>
When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.
Keeping a constant residence time is a well-est…