Search results for " resin" in Articles / App Notes
Article
Selection Guide Size Exclusion Chromatography Columns and Media
Size exclusion chromatography (SEC), also called Gel filtration (GF), separates molecules on the basis of differences in size as they pass through a SEC medium packed in a column. A variety of media…
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Lessons Learned Accelerate Vaccine Development
High-throughput and single-use technologies are also being leveraged to accelerate key aspects of manufacturing processes, such as determination of appropriate media, resins for purification, formulat…
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Continuous Processing for the Production of Biopharmaceuticals
The increased use of multimodal resins and single-use technologies can also play an important role in continuous operation.
Individual efforts made by different researchers to make unit operations…
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Developing Cleaning-in-Place Protocols
A study with a Protein A resin illustrates the approach in this application note.
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Using Xcellerex™ mixing system as a slurry tank when packing chromatography columns
This application note describes the performance of single-use Xcellerex XDM Quad Mixing System used as a slurry tank when packing chromatography columns. The capability of the mixing system to keep …
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Selecting a Comprehensive Bioburden Reduction Plan
Chromatography resins, for example, are not typically provided sterile or capable of being sterilized, so they are a potential source of contaminations unless cleaned, sanitized, and stored correctly.…
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Aseptic Processing: Keeping it Safe
“How much heat is added to the system is a function of container design, type of plastic resin used, and the fill volume,” he says. “The product temperature can be controlled to the point of fill and …
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Use of Multivariate Data Analysis in Bioprocessing
In yet another application, chemometrics has been applied to predict column integrity and impurity clearance during reuse of the chromatographic resin (24). The authors in that study presented a metho…
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Quality by Design and Extractable and Leachable Testing
A supplier’s pharmaceutical application for a component or resin may be a small piece of its overall business profile, particularly for commodity-type components like metal springs or plastic pieces. …
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Trends in Single-use Bioreactors
Establishing full traceability of raw materials, robust process controls, and meaningful specifications from the polymer resin to the finished bag is crucial. Another issue is related to high cell den…