Search results for " buffer" in Articles / App Notes
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
A typical monoclonal antibody (mAb) process may require 2000 L of a buffer and more than 100,000 L per batch based on titer and bioreactor volume (1, 2). As a result, the variety of buffer solutions u…
Article
Will My Buffers Work When Using an Inline Conditioning System?
In-line preparation of buffers from highly concentrated, single-component stock solutions saves both time and storage space. Compared with preparing one concentrate per buffer formulation, many differ…
Article
Make buffer preparation more time and cost efficient with inline conditioning
Preparation of these buffers is a challenge that in-line conditioning can overcome. Inline conditioning simplifies buffer preparation and offers significant reduction in number of tanks, buffer soluti…
Article
Efficient chromatography buffer prep with inline dilution
We also compare the process economy of ILD versus manual buffer preparation — which is still the most common way to prepare buffers — by looking at the labor time, buffer volumes, floor space, and req…
Article
Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
This application note describes a lean approach to buffer preparation by implementing in-line conditioning (IC). Buffers of different formulations for a mAb chromatography capture step were prepared i…
Article
Overcoming Buffer Challenges With In-Line Conditioning
In this application note, we show how in-line conditioning (IC) can help reduce the number of hold tanks and floor space needed for buffer preparation and storage. With IC, buffers of desired formulat…
Article
Buffer Management Solutions for Large-Scale Biomanufacturing
This article discusses solutions such as inline conditioning, outsourcing buffer preparation, and more.
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Article
Automated Buffer Preparation – Increasing Production Capacity While Maintaining Footprint
In fact, buffer preparation is known to be one of the most resource-intensive activities in biomanufacturing, as large volumes of buffers and process liquids are often required as production capacity …
Article
From Bottlenecks to Breakthroughs: Mastering Buffer Management
Agenda
- Options to intensify buffer preparation from using pre-made buffers or buffer concentrates to implementing inline dilution or inline conditioning.
- Considerations for calculating the…
Article
Can You Trust a Machine for Downstream Bioprocess Buffer Preparation?
Still, resource-intensive buffer preparation has received little attention in biomanufacturing. Some of the questions to be answered are:
- Can automated buffer management solutions save resour…