Search results for " conjugate" in Articles / App Notes
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Will the facility be manufacturing monoclonal antibodies, recombinant proteins, vaccines, antibody-drug conjugates, or fragment antibodies? Also, will the products be mammalian cell-derived or microbi…
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mAbs to Watch in 2016
Inotuzumab ozogamicin—Pfizer’s drug candidate for the treatment of acute lymphoblastic leukemia (ALL) is the only antibody-drug conjugate on the potential approval list for 2016. The drug received a B…
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Best Practices in Qualification of Single-Use Systems
Ducry, Antibody-Drug Conjugates (Humana Press, 2013).
Article
Aseptic Processing: Keeping it Safe
Many newer facilities, such as SAFC’s new antibody-drug conjugate-focused floor in its St. Louis, MO campus, have spaces that are designed to handle media fill for various types of products and have i…
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Host-Cell Protein Measurement and Control
Then, detection antibodies, conjugated directly with an enzyme or through a biotin-avidin magnification, bind to the captured HCPs. An enzyme, commonly horseradish peroxidase (HRP), can catalyze the s…
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High-Throughput Process Development in an Historical Environment
The value of HTPD methodology was helpful, with different aluminum salts and different types of vaccines (virus-like particles, polysaccharide conjugates, and proteins) evaluated.
Winning an Oly…
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Pharma Investments Reflect Key Industry Trends
Shrinking facility size, growth of biologics, and emerging market demand influence pharma investments.
Aug 2, 2014
By: Cynthia Challener, PhD
Pharmaceutical Technology
Volume 37, Iss…
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Analyzing Proteins Using SEC, MALS, and UHPLC
Some also notes that for proteins conjugated to a modifier such as glucose, polyethylene glycol (PEG), or surfactant micelles for which no standard SEC reference molecules exist, the combination of MA…
Article
Trends in BioPharma Approvals in 2013
This drug is Herceptin to which a small cytotoxic molecule (DM1) has been conjugated, and like Herceptin, it is approved for the treatment of HER2-positive metastatic breast cancer. As in the case of …
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
HPCE methods for the identification and quantitation of antibodies, their conjugates and complexes. J Pharm Biomed Anal. 1997;16:377–93.
19. Hunt G, Nashabeh W. Capillary electrophoresis sodium do…