Search results for " mixing"
Article
The use of Xcellerex™ mixing system as slurry tank when packing chromatography columns
The capability of the mixing system to keep the chromatography medium (resin) in suspension and the possibility to integrate the system in column packing were studied. The results show that XDM Quad …
Article
Mixing dynamics in a large volume single use mixer
Large-volume mixers are mainly required in clinical three-scale and production-scale facilities where mixing efficiency is one of the key drivers of throughput efficiency. Upstream applications such …
Poster
Heating-cooling and liquid-liquid mixing characterization at a range of volumes
Heating/cooling and mixing properties are the two key parameters important for mixing applications and are needed when comparing the performance between stainless-steel and single-use mixers. In this …
Article
Using Xcellerex™ mixing system as a slurry tank when packing chromatography columns
The capability of the mixing system to keep the chromatography medium (resin) in suspension and the possibility to integrate the system in column packing were studied. Further, an evaluation of the ef…
Article
Fundamentals of Mixed Mode (Multimodal) Chromatography
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Article
Tools for Continuous Bioprocessing Development
A paper from ETH Zurich (funded by Novartis) demonstrated that geometric similarity fundamentally does not allow for scale invariance (from 3 L to 15,000 L) of kLa, shear stress, and mixing time simul…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.
By Alex Chatel and …
Article
Single-use Bioreactors Have Reached the Big Time
“When considering the workflow and objectives of running bioreactors, recent developments have focused on reducing complexity, improving mixing to achieve higher volumetric mass transfer coefficients …
Article
Modeling Bioreactor Performance
In general, process-specific data must also be generated to perform these modeling studies because oxygen transfer and mixing times differ depending on the medium used and the bioreactor fill volume a…
Article
Process Chromatography Selection for Downstream Processing Applications
Also, the ability to use concentrated buffer components and mixing them in-line under controlled conditions (in-line conditioning) has simplified the chromatographic operation. Other simplifications a…