Search results for " purification" in Articles / App Notes
Article
Modeling the Degradation of mAb Therapeutics
Buffer exchange was used to monitor the aggregation kinetics of this mAb under the conditions that are prevalent in the biopharmaceutical industry during downstream purification.
Detailed expe…
Article
Understanding Validation and Technical Transfer, Part I
Large-molecule drug products and attendant manufacturing processes often involve complex syntheses and purification steps that differ substantially from those employed for small-molecule pharmaceutica…
Article
Combine Chromatography Techniques: Get the Right Purity/Yield of Protein
This attractive wall poster shows you how to effectively combine techniques and succeed in your protein purification.
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Article
Reducing Cross-Contamination Risks in Process Chromatography
“With typical bioprocessing tools, a lot of effort and care goes into cleaning and cleaning validation of contact surfaces since any contamination in the purification process can be detrimental to the…
Article
Fusion Proteins Pose Manufacturability Challenges
“These fusion proteins include an Fc region, are taken from an IgG, that extends the serum half-life of the fusion partner, facilitates expression, and allows purification by protein A affinity chroma…
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
For efficient operations, downstream purification needs to be able to handle high product titers at short process time. Compared with conventional chromatography, using stainless steel columns, the us…
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Processed primary animal origin materials are derived after a series of processing steps such as extraction, precipitation, or purification. Examples include: bovine serum albumin (BSA), human serum a…
Article
Continuous Processing for the Production of Biopharmaceuticals
Moreover, the proposed unit can seamlessly be placed in a continuous bioprocessing train, taking input from an inclusion body solubilizing unit and providing the output to a suitable continuous purifi…
Article
Updated Ion Exchange Chromatography (IEX) Handbook
The update brings Sepharose and Capto IEX media together in the same book and the contents will ensure you get the most from your purification runs.
In addition to a new chapter on large-scale pur…
Article
Selecting the Right Viral Clearance Technology
Processes from the other categories are typically steps optimized for product purification and not dedicated for viral clearance. These steps can, according to Strauss, provide acceptable clearance bu…