Search results for " purification" in Articles / App Notes
Article
Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
Article
Technology Innovations Improve Process Chromatography Performance
Recent developments in process chromatography have addressed challenges in downstream separation and purification and led to improved bioprocessing.
Current challenges
The biopharmaceutical ind…
Article
Gene Therapies Push Viral Vector Production
Learning how process parameters in the upstream process influence the purification process is fundamental for a good quality-by-design strategy. Furthermore, it will be interesting to see the developm…
Article
Re-use of Protein A Resin: Fouling and Economics
Bracewell
BioPharm International
Volume 3, Issue 28
In the past two decades, Protein A affinity chromatography has remained the de facto capture step for purification of monoclonal antibod…
Article
Next Generation Process Chromatography
One of the main remaining challenges is that each purification cycle today typically takes >3 hours, and when considering ancillary operations, a typical bioprocess designed today will usually run thi…
Article
Optimization of Protein Expression in Escherichia Coli
Many problems are associated with protein expression, including toxicity, misfolding and degradation, aggregation in inclusion bodies, low yields, and difficulties in purification. One of the most com…
Article
Cytiva Advances Fiber Chromatography Technology with New Launch
27, 2021, Cytiva announced the launch of HiScreen Fibro PrismA, the newest product available for early monoclonal antibody (mAb) purification process development. The product complements HiTrap Fibro …
Article
New Therapies Present Scaling Challenges
The downstream purification process can be scaled up, as the purification process for a gene therapy can use similar hardware as is used in mAb purification.
“In general, purification processe…
Article
The Challenge of Disruptive Technologies in Bioprocessing
The biomolecule purification scheme can be very complex, particularly in the case where affinity solutions are not available, Terova continues. Purification can typically include four to five chromato…
Article
Impurity Testing of Biologic Drug Products
“Other host cell proteins and binding agents carried over from purification columns may mimic the action of the therapeutic protein in assays, leading to mis-formulation of the product outside the the…