Search results for " monoclonal" in Articles / App Notes
Article
Viral Clearance Challenges in Bioprocessing
Challenges remain for virus removal and validation.
Nov 1, 2014
By: Cynthia Challener, PhD
BioPharm International
Volume 11, Issue 27, pp. 42-44
Removal and inactivation of adventitio…
Article
High-Throughput Process Development in an Historical Environment
…gh throughput techniques and different formats were used to identify the effect of ligand density in monoclonal antibody (mAb) purifications. Two different novel multimodal polishing Capto™ ImpRes re…
Article
Setting Standards for Biotech Therapeutics in India
Many new general chapters pertaining to topics such as therapeutic monoclonal antibodies, host cell proteins and DNA, and viral safety are in the works for the next IP edition.
As mentioned previo…
Article
Biopharma Manufacturers Respond to Ebola Crisis
Most discussed is the ZMapp cocktail of three monoclonal antibodies from Mapp Biopharmaceutical of San Diego, which made headlines when two American health workers infected by Ebola recovered followin…
Article
Continued Process Verification for Biopharma Manufacturing
Its recommendations are based on a typical cell culture production process for making a fictitious monoclonal antibody (mAb) product (3). Although this model plan does not provide examples of all aspe…
Article
Application of Quality by Design to Viral Safety
In two recent papers, Genentech (a member of the Roche group) reported on work it has conducted on developing viral clearance process design spaces for two unit operations commonly used in monoclonal …
Article
Healthcare Reform in China
Chinese healthcare reforms may be a double-edged sword for foreign companies.
Sep 1, 2014
By: Jane Wan
BioPharm International
Volume 27, Issue 9, pp. 8-12
On March 25, 2014, the…
Article
Single-Domain Antibodies for Brain Targeting
Going single domain
Biologic therapies such as monoclonal antibodies (mAbs) are enabling the targeted, personalized treatment of cancer, inflammatory diseases, infectious diseases, and diseases of…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Three recombinant Chinese hamster ovary (CHO) cell lines, developed in-house to produce three different monoclonal antibodies, were used in this study. Cell lines A and B are dihydrofolate reductase-d…
Article
Q&As with Industry Leaders
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Jeanne Linke Northrop, BioPharm International
Jakob Liderfelt, Global Product Manager, Monoclonal Antibody Polishing, Cytiva
Top challenges in recombinant protein purification…