Search results for " surfac" in Articles / App Notes
Article
Modeling the Degradation of mAb Therapeutics
In the primary structure, a protein is more susceptible to instability if there is change in its surface charge distribution or hydrophobicity. Alterations in the secondary structure, especially an in…
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Scaling Up Novel Therapies
The reactors are designed so that a very large surface for cell growth is packed inside a small volume, reducing the number and complexity of operations compared with traditional equipment, he says. T…
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Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Analytical exoglycosidases are transitioning from being largely academic tools to being s…
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Ensuring Viral Safety of Viral Vaccines and Vectors
UV-C irradiation has been used in the food, plasma, and biotech industries (for packaging and surface sterilization) and is effective against various biological contaminants, including bacteria and vi…
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Videos! SPR Applications in Protein Characterization
In these exclusive videos from the Biacore Analytical, Comparability and QC Symposium, Vienna, November 2017, industry thought-leaders share insights, tips, and techniques that illuminate how SPR with…
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Sensitive and Reproducible SPR-Based Concentration and Ligand-Binding Analyses
Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This art…
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Impurity Testing of Biologic Drug Products
“Examples include growth selection agents, surfactants, purification column binding agents, and viral inactivation agents.”
“The use of cells and growth media in the production process al…
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Preclinical Evaluation of Product Related Impurities and Variants
…r, GCSF-R, preferably using a label-free, optical-based technique such as biolayer interferometry or surface plasmon resonance spectroscopy; cell based assays on cell lines that express GCSF-R (Leuke…
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Reducing Cross-Contamination Risks in Process Chromatography
“With typical bioprocessing tools, a lot of effort and care goes into cleaning and cleaning validation of contact surfaces since any contamination in the purification process can be detrimental to the…
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Impact of Media Components on CQAs of Monoclonal Antibodies
Acidic fibroblast growth factor (FGF) readily degrades if heparin sulfate is not present on the surface of the target cells; therefore, heparin or synthetic dextran as a substitute is added to the med…