Search results for " design"
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Reconciling Sensor Communication Gaps
Process analytical technology (PAT), quality by design, and individual company- or process-centric quality initiatives are driving the development of bioprocess sensors and probes. Single-use systems …
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Automating Bioprocesses
With traditional systems, sensors were designed to be highly accurate, long-lasting devices. In SUS, these sensors would be too expensive, because the sensor only needs to last for one batch. Disposab…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Custom designed stainless-steel cases lined with foam padding (designed to protect the bags while in the frozen state) were used as containers for the ~8.3 L bags during storage and handling.
Size…
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Improving Process-Scale Chromatography
For example, Cytiva is currently using high-throughput screening techniques to screen hundreds of ligand designs with the goal of further improving process economy and robustness in mAb manufacturing …
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Vaccine Development Faces Urgency and Challenges
Experts seek to improve public health infrastructure and to reach global agreement on clinical trial design and regulatory decision making to support rapid development of needed therapies. At a Minist…
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Lessons Learned Accelerate Vaccine Development
The company was able to rapidly evaluate the design space of the process and identify critical process parameters due to its extensive knowledge of its AdVac (adeno virus) and PER.C6 platform technolo…
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Continuous Processing for the Production of Biopharmaceuticals
Multiple tools are now available to design a continuous process, and researchers have demonstrated the tools’ successful use in a large variety of applications.
Table I: Summary of recent e…
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Reusability of culture substrates
Some responsive substrates designed to promote cell detachment under the effect of a particular stimulus undergo an irreversible structural modification that prev…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
SPR analysis is widely used in research where antibodies are either designed for improved interaction with Fc-γ receptors (29) or for the elimination of immune effector functions when non-immunostimul…
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Trends in Single-use Bioreactors
In addition, there are new systems now specifically designed for microbial fermentation.
Ang (Eppendorf): Most notable is the innovation of single-use bioreactors suitable for microbial fermenta…