Search results for " throughput"
Article
Host-Cell Protein Measurement and Control
…e 1), remains as the industry gold standard for HCP measurement due to its high sensitivity and high throughput (3, 5). The HCP composition and abundance are unique to their respective host and the m…
Article
Ligand-Binding Assays and the Determination of Biosimilarity
Advances in SPR analysis have resulted in increased robustness of the assays and reduced operator influence, as well as increased throughput for the determination of binding affinities. Biolayer inter…
Article
Improving PAT for Biologics
High throughput methods
High-throughput process development systems and rapid analytical methods have the potential to reduce both the labor and time required to study both the many different vari…
Article
A Q&A With Dr. Anurag Rathore About the Future of QbD, Part I
Examples of such tools include high throughput process development, computational fluid dynamics, and use of advanced statistical approaches for designing experiments, analyzing data, and process cont…
Article
A Q&A With Phil Lester, co-organizer of the HTPD Conference
Can you tell us about the genesis of the conference?
Phil: Back in 2008 high throughput process development was an emerging technology and I could see it was going to be a game-changer. I thought …
Article
Analyzing Proteins Using SEC, MALS, and UHPLC
Greater throughput with smaller particle sizes
Several evolutionary advances in SEC have had a positive impact in recent years. Smaller flow cells and improved cell design, for example, have made …
Article
Challenges in Analytical Method Development and Validation
Depending on the intended use of the method, typical performance criteria (accuracy, reliability, specificity, sensitivity, range, robustness/maintenance, as well as speed and throughput capacity, but…
Article
Best Practices in Adopting Single-Use Systems
Conclusion
Choices made when specifying single-use equipment can have cascading and lifecycle-long effects on process throughput, cost, efficiency, and risk. Adopting disposable bioprocessing by ju…
Article
Evolution of the Monoclonal Antibody Purification Platform
With the high throughput that membrane adsorbers provide, this could be a promising addition to the antibody purification platforms.
Summary
It is evident that many alterations to the mAb plat…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
It also will become necessary to increase the throughput of nanofiltration devices, so that they do not become the next process bottleneck. In addition, we must develop new technologies for ultrafiltr…