Search results for " system"
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
The results were used for scaling up the process to a ReadyToProcess WAVE 25 bioreactor system at a 2-L working volume. The data show that the ADCF process using VaccineXpress for rotavirus propagatio…
Article
New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
Article
Methods Accelerate Biosimilar Analysis
The new generation of mass spectrometers, including time-of-flight (ToF) instruments, as well as hybrid systems such as quadrupole (Q)–ToF, ion trap–ToF or ToF–ToF, and orbital ion trap mass spectrome…
Article
Addressing the Complex Nature of Downstream Processing with QbD
The International Council for Harmonization (ICH) defines QbD as a systematic approach that incorporates prior knowledge, results of studies using design of experiments (DoE), use of quality risk mana…
Article
Fiber-Based Protein A Chromatography for HTPD
The novel cellulose fiber technology (known as Fibro) may be used with ÄKTA™ chromatography systems and autosamplers to reduce process time significantly compared with conventional chromatography…
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product qu…
Poster
Scaling In-Line Buffer Preparation from Process Development to Manufacturing
This poster demonstrates how ÄKTA™ avant can be used to replicate the BioProcess™ IC System in bench scale.
Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
…a 50-fold scale-up of a three-column PCC (3C PCC) mAb capture step within the lab-scale ÄKTA™ pcc system and a 294-fold scale-up directly from lab to manufacturing scale.
Download poster her…
Article
Multistep Protein Purification: Gain Time and Consistency
In this webinar, "Gain Time and Add Consistency with Automated Multistep Protein Purification," the presenters discussed the benefits of automation, how to set up an automated purification protocol,…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Finally, enzymes were manufactured under international quality management systems to ensure a high level of traceability and quality control.
Figure 4. A) Physical quality of comme…