Search results for "Mabs" in Articles / App Notes
Article
Modeling the Degradation of mAb Therapeutics
This is particularly true for monoclonal antibodies (mAbs), which account for most commercial biopharmaceuticals today. Both physical effects such as aggregation and chemical modifications (e.g., frag…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
…velopment of robust, efficient, and economic purification strategies for new monoclonal antibodies (mAbs) coming through the pipeline. Since the first therapeutic antibody came onto the market in 198…
Article
mAbs to Watch in 2016
mAbs in development
Most of the products listed below are in Phase III trials; however, a few are in earlier stages of development. Although the pharmaceutical manufacturers developing these mAbs …
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Therapeutic monoclonal antibodies (mAbs) represent a rapidly growing area in the biopharmaceutical sector (2). Enormous success achieved with mAbs can be attributed to their distinctive beneficial pro…
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Innovative approaches, including ready-to-use materials and in-line dilution, can significantly streamline overall bioprocessing operations.
By: Pranav Vengsarkar and Nandu Deorkar
I…
Article
Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
Read the full article >>
In clinical monoclonal antibody (mAb) manufacturing, capture on protein A chromatography resin gives excellent recovery and purity. However, because clinical batch siz…
Article
Strategies and Emerging Technologies for mAb Capture
View this on-demand webcast >>
In this webinar, we will describe and evaluate different process intensification strategies for the monoclonal antibody (mAb) capture step. Strategies wi…
Article
Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…
Article
Get Started: Purification of mAb Variants - eLearning
Purification of bsAbs and antibody fragments isn’t as straightforward as for mAbs. These molecules show wider variation in binding affinities and are often more challenging to separate from impurities…
Article
Pulling Out All the Stops in mAb Manufacturing
The need for good manufacturing practice compliance for mAbs going forward is increasingly crucial.
Learn more here