Search results for " bioprocessing" in Articles / App Notes
Article
Improving PAT for Biologics
With respect to the use of PAT in downstream bioprocessing, François suggests that a lack of good real-time online measurement techniques may be a limiting factor. There has, however, been significant…
Article
Continuous Processing for the Production of Biopharmaceuticals
While there is a plethora of emerging continuous bioprocessing technologies available in the market, there are almost no concrete examples of successful implementation and integration of a fully conti…
Article
Evaluating the Use of Continuous Chromatography
BioPharm: What is continuous chromatography, and how has it improved downstream bioprocessing?
Rozanas (Cytiva): Continuous chromatography differs from traditional ‘batch’ chromatography in two ke…
Article
Improving Upstream Predictability
“PAT has matured and is used more routinely now, through in-line pH, dissolved oxygen and carbon dioxide sensors, while use of Raman spectroscopy is increasing,” notes Darren Verlenden, head of biopro…
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The Need for Advanced Process Modeling for New Therapeutic Biologics
As bioprocessing workflows increasingly shift toward automation, the approach to modeling also needs to evolve to incorporate next-generation tools and software. For example, how would process modelin…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Reduction in bioprocessing time is one advantage that single-use systems offer. As Young points out, reusable systems can typically require more than 12 hours from set-up to tear-down, while single-us…
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The New World of Biopharmaceutical Manufacturing
Linz (Sartorius): In the past couple of years, we have seen just about every bioprocessing technology become available in a fully single-use format. Companies are implementing end-to-end single-use pl…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Use of a subspace model is a viable method to characterize process space variables and optimize process performance.
By Colin Jaques, Daniela Lega
Over the past decade, two improved capabili…
Article
Top Process Development Trends for 2021 and a Look into 2022
The COVID-19 pandemic continues to shape bioprocess development trends, and many lessons have been learned from industry’s response to and preparedness for dealing with a public health crisis. Howev…
Article
Tools and Processes for Mature and Emerging Therapies
In April 2019, at the INTERPHEX trade show in New York City, vendors of bioprocessing equipment and materials announced improvements to existing platforms, added options for upstream and downstream sy…