Search results for " mammalian"
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Vaccine Development and Production Challenges Manufacturers
Novartis’ vaccine plant in Holly Springs, NC was recently licensed to produce Flucelvax using mammalian cell culture. But the plant’s future is murky following Novartis’ divestiture of most of its vac…
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Improving PAT for Biologics
Beri, head of mammalian research and technology for Lonza Custom Development and Manufacturing. In addition, PAT is much more than just one sensor integrated into a process. “Effective PAT implementat…
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Challenges of Protein Aggregation During Purification
Cytiva recently announced a licensing agreement with Promosome, a company with a technology for improved protein expression in mammalian cells. “We have hope that Promosome’s technology will be a bett…
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Monoclonal Antibodies Key to Unlocking the Biosimilars Market
In addition, it is quite expensive to develop more complex biosimilar mAbs, as much as a $200 million investment for one candidate, including the necessary mammalian cell culture facility built in com…
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Trends in BioPharma Approvals in 2013
In terms of expression systems used, a total of eight of the products approved are expressed in mammalian cell lines (seven in CHO cells, one in Sp20), six are produced in yeast-based systems, four in…
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The Development and Application of a Monoclonal Antibody Purification Platform
Recent advances in mammalian cell culture technology have resulted in significant increases in upstream productivity, with antibody titers of >5 g/L becoming increasingly common. Such increases could …
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Milestones and Moderate Progress in 2012 Drug Approvals
These figures once again reflect the ongoing dominance of mammalian-based expression systems in terms of biopharmaceutical manufacture.
Digging a little deeper reveals that the majority …