Search results for " columns"
Article
Sanitization of AxiChrom™ Columns Packed with Chromatography Resin
This study evaluates sanitization methods based on 1 M sodium hydroxide (NaOH) as sanitization agent using methodology previously developed for peracetic acid (PAA).
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Article
Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
Article
New Selection Guide: Ion Exchange Chromatography Columns and Resins
Use these decision trees to find the most appropriate resin for your needs.
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Article
Optimizing Resin Performance with Disposable Chromatography Solutions
The experts addressed how disposable chromatography columns can be used throughout the life of a campaign, the costs and benefits associated with using prepacked columns, the complexities of resin str…
Article
Process Chromatography Selection for Downstream Processing Applications
Periodic counter current chromatography (PCC) allows overloading of columns and continuous loading at the same time. Arranging two different modes of chromatography in series, operated with or without…
Article
Making the Move to Continuous Chromatography
In continuous multicolumn chromatography, the large column is effectively split into a number of much smaller columns that operate in series over a larger number of cycles. While product is loaded on …
Article
Re-use of Protein A Resin: Fouling and Economics
An additional concern is that the ability of chromatography columns to clear adventitious viruses may also be reduced with extended use (20). In view of this, there is a need to continuously monitor p…
Article
SEC in the Modern Downstream Purification Process
This large difference eliminates the need to increase the bead particle size to allow for columns with longer bed heights to be packed, and eliminates the need for a column with a long bed height alto…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
By Anurag Rathore, Vijesh Kumar
Among the various downstream processing unit operations that are used for purification of biotech products, chromatography is uniquely capable of providing resolu…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
PEGylation dramatically changes the chromatographic properties of proteins such that loading capacity is severely compromised thus requiring larger columns (33, 34). Additionally PEGylation can dramat…