Search results for " protein" in Articles / App Notes
Article
Developing Cleaning-in-Place Protocols
A study with a Protein A resin illustrates the approach in this application note.
Article
ÄKTA Laboratory-Scale Chromatography Systems Handbook
This handbook is focused on liquid chromatography systems used for protein purification at research laboratory scale. Beginners can use the handbook to obtain an overview of how purification systems…
Article
Labeling of Biosimilars
In December 2014, guidelines on quality standards for biosimilars with proteins as an active substance came into effect (1), while guidance on clinical and non-clinical issues with the products was be…
Article
Technologies and Practices Must Evolve to Meet Demand
Respondents to the 2015 survey who develop or manufacture protein-based drugs expressed less concern about protein stability challenges than their counterparts did in 2014. Regulatory issues and micro…
Article
A Q&A With Phil Lester, co-organizer of the HTPD Conference
For the Olympiad, Cytiva created a kit containing a target protein in a crude feedstock along with a variety of chromatography media and suggested analytical methods. The goal is to purify the target …
Article
Trends in BioPharma Approvals in 2013
Like Genentech’s already well-established product Rituxan (rituximab), Gazyva targets the CD20 surface protein associated with B lymphocytes and is approved to treat chronic lymphocytic leukaemia, one…
Article
Bioprocessing Advances in Vaccine Manufacture
coli) for recombinant protein expression are further making vaccine manufacture easier and cost-effective and reducing the scale and investment required to manufacture products. The BioPlan annual sur…
Article
Report from the Eighth International Plasma Product Biotechnology Meeting Melia Salinas, Lanzarote, Spain
On a similar theme, the prion removal capacity of existing plasma protein manufacturing processes was presented by Nathan Roth at Grifols. The extensive study was based on a joint data collection from…
Article
Optimizing KiH bispecific antibody chromatography steps
… optimized capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through polishing steps using o…
Article
Selected courses from cell culture and downstream process development to scale-up and manufacturing
…reactor scaling
Filtration in bioprocessing
Purification of mAb variants
DoE in protein purification
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