Search results for " protein" in Articles / App Notes
Article
Reviewing the Importance of Biosimilarity and Interchangeability
Stamm also points out that analytical methods should be established to identify and quantify residual host cell proteins to ensure they are within acceptable limits because their presence could impact…
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Free handbook for column packing and maintenance
Does large-scale column packing seem daunting? Impossible to get right? This new handbook can help! Packed with valuable guidance for using AxiChrom™, BPG and Chromaflow™ columns, you’ll disco…
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Evaluating the Use of Continuous Chromatography
In downstream processing, continuous chromatography is gaining traction in the purification of protein therapeutics. As the biopharmaceutical industry strives to demonstrate, continuous manufacturing …
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You are invited to attend DiPIA 2024
DiPIA, or Developments in Protein Interaction Analysis, is a global scientific conference hosted by Cytiva. We bring peers together from across the industry to share best practices, research, and new …
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Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
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Chromatography innovations for the diversified antibody pipeline
Introducing MabSelect™ VH3 affinity resin for antibody variants
At Cytiva, we connect with process developers and manufacturers to understand their needs and strive to make t…
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Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
There is a vast array of antibody variants, including multispecific (msAb), bispecific antibodies (bsAb), antibody fragments (Fab, dAb, scFv), and antibody-drug conjugates (ADC). But with this…
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Digitalization: The Route to Biopharma 4.0
However, there are many attributes such as charge variant, aggregates, host-cell proteins, and bioburden that cannot be measured online at present and require sampling and offline analysis (19). Creat…
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Benefits of DoE vs mechanistic modeling
Hear about the main differences between mechanistic modeling and design of experiments when used during chromatography process development. You will learn that, quite often, these methods work…
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Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…