Search results for " process" in Articles / App Notes
Article
Validation of the production of influenza virus in ReadyToProcess WAVE™ 25 bioreactor system
A 2 L process, developed using the predecessor WAVE Biorector™ 20/50 system, was used as a starting point. Compared with WAVE Biorector™ 20/50, the successor ReadyToProcess WAVE 25 system allows using…
Article
Establishing Acceptance Criteria for Analytical Methods
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Knowing what is the allowable contribution of the method error in drug performance becomes crucial when building product knowledge, process understanding, and the associated long-term product l…
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
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Overcoming Buffer Challenges With In-Line Conditioning
Preparation and storage of the large number of buffers required for biopharmaceutical production can be a challenge, particularly in large production scale. In this application note, we show how in-…
Article
A Second Modular Biopharma Facility Opens: KUBio in Hangzhou
KUBio modules are pre-fabricated with Cytiva’s Flexfactory processing technology that significantly reduces construction and installation time. The center will also include filling and packaging lines…
Article
Selection Guide Size Exclusion Chromatography Columns and Media
Download this handbook to make the selection process easier.
Article
Reporting Quality Metrics to FDA
… batches, compared with a site that produces large volumes of just a couple of products in dedicated process trains.
In addition, it is crucial to ensure that all parties involved understand what…
Article
KUBio modular biopharm facility built in Germany, assembled in China
Cytiva is supplying a full biopharmaceutical processing solution, known as a KUBio, to JHL Biotech in Wuhan, China. The sixty-two completed modules that make up the factory have completed the journe…
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Fed-batch supplements to boost cell culture performance
To increase the yield of a target protein, fed-batch culture is often employed in biomanufacturing processes. This application note demonstrates the enhanced performance of commonly used cell lines …
Article
E. coli growth and Dab expression in single-use and stainless steel fermentors
coli domain antibody (Dab) production process developed for a stainless steel fermentor. Cell growth,
cell density, and Dab expression levels were assessed and compared between the two production…