Search results for " downstream"
Article
Strategizing for Rapid Changeovers in Biologics Manufacturing
Inclusion of multiple upstream suites can enable better utilization of downstream operations because upstream processing takes much more time, according to Stenklo.
For a multi-product downstream …
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
…hain, and concerns about potential problems caused by extractables and leachables, especially during downstream operations, need to be addressed through appropriate studies. The requirement for great…
Article
Modeling the Degradation of mAb Therapeutics
They result in instabilities that can occur at various stages of product development, including upstream processing (during protein expression in cell culture), downstream processing (purification), p…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Readers also wanted to learn about specific solutions for downstream processing, with another hot article being an application note describing the development of downstream chromatography steps for th…
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
Continuous processes currently are implemented in commercial manufacturing for upstream operations but not for downstream processes, the panelist noted. There is some potential for continuous manufact…
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Industry Adoption of Single-Use Systems Remains Low
Now we have a complete portfolio of single-use upstream and downstream systems for bioprocessing, including rocking and stirred tank bioreactors, sensors, smart mixers, filtration pump skids, virus in…
Article
Impurity Testing of Biologic Drug Products
In practice, additives are required for cell growth, non-target proteins will be extracted, and downstream processing will occur, so purification steps are paramount. Control of these steps must be de…
Article
Fusion Proteins Pose Manufacturability Challenges
Combining two different proteins in one molecule can lead to instability, which creates manufacturing challenges during both upstream and downstream processing. Solutions for overcoming these issues a…
Article
Automating Bioprocesses
By Jennifer Markarian
Both upstream and downstream biopharmaceutical processes have conventionally used stainless-steel equipment, but use of single-use systems (SUS) is becoming more established.…
Article
A Q&A with Eric Langer: CMOs Embrace New Technology
In comparison, biopharmaceutical innovators sought improved analytical assays and development, control systems, fill-finish services, and downstream PD services.
Why are CMOs early adopters?
…