Search results for " downstream"
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
But because the chosen methods focused primarily on downstream virus removal or inactivation instead of strategic sourcing of lower-risk starting materials, the efforts had little effect on serum-free…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Process compatibility
Some chemicals necessary for particular cell-detachment procedures may interfere with subsequent downstream processing steps that are unaffected by other alternative detachme…
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Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Viability at harvest was substantially increased for both cell lines with positive implications for the downstream process.
Figure 5: Comparison of (A) c…
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CMOs Concerned With Cost of Single-Use Equipment
Given that CMOs expect to increase their budgets by as much as 6% for new technologies to improve upstream and downstream efficiency—with single-use equipment presumably a part of this spending—budget…
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Biopharma Advances Demand Specialized Expertise
The main roadblock for continuous processing is downstream processing of proteins, which currently demands discrete and distinct unit operations for removal of impurities, removal of contaminants, con…
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Ligand-Binding Assays and the Determination of Biosimilarity
… LBAs are developed by upstream analytical method development groups and subsequently transferred to downstream QC-GMP lot release groups.”
Ligand-binding kinetic assays for biosimilarity testing…
Article
What Drove Biopharma Development in 2014?
In 2014, there was significant increased interest in continuous processing, both upstream and downstream. On the PDF site, this trend was evident based on webinar invitations, as well as in published …
Article
Securing the Single-Use Supply Chain
Large-scale impact
Today, single-use systems are used throughout the entire process chain from upstream to downstream and from bench scale to production scale. In the past, when drugs were manufac…
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Mechanistic Modeling: Does it Have a Future in Process Development?
Novo Nordisk uses mechanistic models for the development of selected downstream process steps. Following his keynote presentation to attendees at the recent HTPD Conference in Italy, Arne Staby, PhD, …
Article
Pharma Investments Reflect Key Industry Trends
Meanwhile, Sanofi’s Genzyme business is investing $80 million at its recently approved facility in Framingham, MA, adding more downstream processing capabilities for Fabrazyme (agalsidase beta), its t…