Search results for " downstream" in Articles / App Notes
Article
Virus-like Particles as Therapeutic Moieties of the Future
Modification of VLPs may also affect their downstream application. Identification of the composition is thus a prerequisite for characterization of VLPs.
Mass spectrometry (MS) is a robust tool to…
Article
Reimagining Affordable Biosimilars
Near-infrared spectroscopic methods find application as process analytical tools in upstream and downstream processing of biotherapeutics, aiding in process control. Unique spectral signature of chemi…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Inclusion of multiple upstream suites can enable better utilization of downstream operations because upstream processing takes much more time, according to Stenklo.
For a multi-product downstream …
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
…hain, and concerns about potential problems caused by extractables and leachables, especially during downstream operations, need to be addressed through appropriate studies. The requirement for great…
Article
Modeling the Degradation of mAb Therapeutics
They result in instabilities that can occur at various stages of product development, including upstream processing (during protein expression in cell culture), downstream processing (purification), p…
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Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Readers also wanted to learn about specific solutions for downstream processing, with another hot article being an application note describing the development of downstream chromatography steps for th…
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Biopharma Says It Has an Evolution in New Technologies and Processes
Continuous processes currently are implemented in commercial manufacturing for upstream operations but not for downstream processes, the panelist noted. There is some potential for continuous manufact…
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Industry Adoption of Single-Use Systems Remains Low
Now we have a complete portfolio of single-use upstream and downstream systems for bioprocessing, including rocking and stirred tank bioreactors, sensors, smart mixers, filtration pump skids, virus in…
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Impurity Testing of Biologic Drug Products
In practice, additives are required for cell growth, non-target proteins will be extracted, and downstream processing will occur, so purification steps are paramount. Control of these steps must be de…
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Fusion Proteins Pose Manufacturability Challenges
Combining two different proteins in one molecule can lead to instability, which creates manufacturing challenges during both upstream and downstream processing. Solutions for overcoming these issues a…