Search results for " titer"
Poster
Unlocking the potential for efficiency in downstream bioprocesses
Upstream processes are more efficient and product higher titers than before. With these improvements, new challenges arise. Downstream processes have to handle higher amounts of both targetprotein and…
Article
Tools for Continuous Bioprocessing Development
These online measurements are supplemented by sample removal for offine measurements of glucose, viability, titer, and product quality (13). The device can use up to 324 cultures simultaneously, allow…
Article
Biopharma in 2015: A Year for Approvals and Innovations
…namic Control in Periodic Counter-Current Chromatography
Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
Trends in Single-use Bioreactors
Process economy and product…
Poster
Benchmarking, scalability, and protein production in CHO cell culture
The most widely used cell lines in the bioprocess industry originate from CHO cells. With the large number of CHO clones in use, it is important to have a cell culture medium that supports high via…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Figure 2: Characterization of titer at harvest for a model two-dimensional process space spanning a range of dissolved oxygen tension (DOT) and pH values.
By using DoE, it is po…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
Therefore, rather then only selecting for clones with the highest titer, as is usually the case for innovator drugs, selection is first for biosimilarity, which may mean that some of the highest produ…
Article
Fluid Handling in Biopharma Facilities
Peuker (Sartorius Stedim Biotech): The customer should be aware of the process he will realize: process volume, process titer, future processes, etc. We made the best experiences with process simulati…
Article
Continuous Chromatography: Trends, Definitions and Approaches
For the very low titer processes, or rather for the cases where the ratio of capacity-to-feed concentration is very high, even a 2-column system will be sufficient.
Can you comment on the import…
Article
Continuous Manufacturing: A Changing Processing Paradigm
These procedures repeat in subsequent columns, helping to balance downstream productivity with upstream titers. Several equipment manufacturers, such as Novasep, Tarpon Biosystems, Cytiva, Semba, and …
Article
Viral Clearance Challenges in Bioprocessing
“Access to high titer virus preparations in testing labs is one way to achieve high clearance levels, and if complete clearance is observed across the unit operations, high log reduction values (LRVs)…