Search results for " MabSelect"
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
… hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these experiments and a discussion of h…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
In this application note, the effects of treating MabSelect SuRe protein A affinity resin with 20 mM PAA every fourth process cycle for more than 100 cycles were investigated. The results show that t…
Article
Re-use of Protein A Resin: Fouling and Economics
Some of the major Protein A resins that are commercially available include MabSelect (Cytiva), MabSelect Xtra (Cytiva), MabSelect SuRe (Cytiva), MabSelectSuRe LX (Cytiva), ProSep Ultra Plus (EMD Milli…
Article
Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…
Article
Capacity and Performance of a Next Generation Protein A Chromatography Resin
The resin exhibits improved capacity over its predecessor MabSelect SuRe™ products, while maintaining purification performance. This application note demonstrates the binding capacity and purification…
Article
Chromatography innovations for the diversified antibody pipeline
Our MabSelect™ VH3 affinity resin interacts with the variable heavy chain of the VH3 sequence family of human antibody, delivering high binding capacity and efficient separation of product-related imp…
Article
As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Cytiva expands the antibody capture resin toolbox and has recently announced MabSelect™ VH3 affinity resin. MabSelect VH3 uses an engineered protein A resin that interacts only with the variable heavy…
Article
Protein L affinity resin is ready to move to manufacturing
The MabSelect™ VL protein L resin now offers improved alkaline stability compared to Capto™ L resin and a two-fold or more increase in dynamic binding capacity (DBC) in certain applications. After com…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Poster
Guide to modern BioProcess™ chromatography resins
Proteins are different. Based on what protein you would like to purify and the conditions used, chromatography resins are selected to optimize purity and yield. Many bioprocess applications include …