Search results for " binding"
Article
Get to know: mAb variants - eLearning
Key learnings are:
- Structure and binding domains for antibody variants
- Advantages and disadvantages of different antibody fragments
- Design strategies for bispecific antibodies (bsAbs)
…
Article
Finding the Needle in a High-Dimensional, Information-Rich Data Haystack Can Be Time Consuming
With these tools, scientists can detect and characterize low molecular weight and low affinity compounds binding to their targets.
Improvements in data analysis software have helped to streamline …
Article
Virus-like Particles as Therapeutic Moieties of the Future
Functional analysis
Functional characterization of VLPs includes assays to evaluate binding ability of drug delivery vehicles to specific target cells, or antigenicity and immunogenicity of vaccin…
Article
Platform for Purification of VHH-type Antibody Fragments
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Protein A affinity chromatography resins have been used to purify monoclonal antibodies (mAbs) by the bioprocess industry at all scales for a long time. Howev…
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Rapid Cycling Protein A-Based Fiber Chromatography to Address Emerging Downstream Bottlenecks
This structure allows high monoclonal antibody (mAb) binding capacities at very short residence times, which reduces cycle times to minutes instead of the hours needed for resin-based chromatography. …
Article
Capto™ High Productivity Resins
Capto™ chromatography resins give you increased productivity compared with Sepharose™ resins, through high binding capacity and high flow rates.
Explore Capto™ resins now >>
Article
Purification of Plasmid DNA
By switching to modern chromatography resins, Cobra Biologics was able to increase binding capacity and flow rates up to 50% to address the increasing demands for high quality plasmid DNA.
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Article
Biosimilar Quality Requirements
Factors to consider include the expression system, the manufacturing process, physicochemical properties, functional activities, target binding, impurities, the reference product and reference standar…
Poster
Comparison of Three Different Screening Techniques for Predicting Step Elution Conditions for a Cation Exchanger
It is important that the screening can give an indication of the optimal conditions for binding and/or elution in a chromatographic column run. The aim of this study was to investigate conditions for …