Search results for " simulation"
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Robust Optimization, Simulation, and Effective Design Space
Once the DOE is complete, the developer can use the DOE to build a process model, define the design space, and run simulations for various optimums and to determine effective factor ranges where the o…
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Do Modeling and Simulation Tools Really Benefit the Biosimilar Industry?
The business impact of modeling and simulation tools is not well understood and requires clarification of their benefits to drug development.
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Simulation gets therapies to patients faster and smarter
Digital solutions are helping to decrease therapeutic time to market but remain challenging – learn how we work on overcoming that challenge!
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It All Adds Up: Mathematical Simulations in Biopharma Research
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Computer simulation helps us design better cars before we make a physical model. What if we could use this technology to do the same for purifying new biotherapeutics? T…
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Simulating chromatography processes in the growing molecular diversity
The increasing complexity and diversity of development pipelines poses new challenges for product manufacturing. Mechanistic modeling can play a key role in overcoming these challenges as they…
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Process Economy Simulations on a Protein A Capture Step
MabSelect PrismA is a next‐generation protein A chromatography resin that offers significantly enhanced alkaline stability and capacity compared with its predecessor products. This application note …
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Process Economic Simulation for Scalable Production of Adenovirus
This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-st…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Scale-down freeze-thaw simulation
Approximately 30 mL and 100 mL of 64 mg/mL mAb-A were filled into 30mL and 100mL bags (Sartorius Stedim), respectively. The 6.2 L fill was a convenient volume…
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Evaluating E&L Studies for Single-Use Systems
The extraction and leachables simulation study conditions presented here were designed to compensate for the insufficient/inadequate extractables data supplied by vendors and were intended to mimic th…
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Evaluating Design Margin, Edge of Failure and Process
To detect the edge of failure and to visualize the design space and associated design margin through simulation, the following process should be performed:
1. Conduct the designed experiment and b…