Search results for " simulation"
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
Jeanne Linke Northrop: I also want to talk a little bit with you about simulations and process development. Digitalization is changing the industry. In terms of using simulations and process developme…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
The resulting data can be used to calculate column porosities and dispersion by fitting the output profile with the estimated profile using CADET simulation with trial values of the parameter.
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Article
Modeling Bioreactor Performance
Analyzing with simulation scenarios, fluid processing and sequencing may yield more practical near-term results than coming up with a novel bioreactor design through modeling,” he notes.
Typically…
Article
Essentials in Establishing and Using Design Space
The goal of simulation is to model 100% of the variation in the process. This includes the variation from the model (RSquare) plus the variation due to other factors and the variation from the analyti…
Article
Digitalization: The Route to Biopharma 4.0
One of the software (python-based) programs named Orbit acts like a digital twin and offers customized real-time control solutions for an integrated system with extra functions such as monitoring, sim…
Article
Accelerating CMC - The future of process development is in silico
In this session, you’ll gain insight on how to apply simulation in your CMC activities, including case studies of the successful use of simulation in biopharmaceutical process development.
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Article
Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer.
By Jennifer Markarian
A digital twin is a model of a proces…
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
Molecular dynamics simulations increase our scientific understanding, while a hybrid of mechanistic and statistic models allows to better cope with uncertainty, noise and trends over production cycles…
Article
Cell-Culture Advances Test Bioreactor Performance Models
Challener
Modeling and simulation are recognized to provide assistance in predicting bioreactor performance, both for initial laboratory runs and when scaling to the pilot plant and commercial ma…
Article
Digitalized PD: Speeding up downstream process development
In silico simulations of chromatography processes based on mechanistic models can be used to run thousands of experiments in very short time.
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